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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1026064Generated: October 31, 2026

(2-Cyclopropylthiazol-4-yl)methanamine → 5-(4-chloro-3-methylphenyl)-N-((2-cyclopropylthiazol-4-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

https://huagongshe.com/reaction/1026064

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2-Cyclopropylthiazol-4-yl)methanamineHCID 45792629—
Reactant5-(4-Chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acidHCID 66678836—
Product5-(4-chloro-3-methylphenyl)-N-((2-cyclopropylthiazol-4-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamideHCID 56929184—

Reaction Steps

The title compound was synthesized in analogy to Example 1 using 5-(4-chloro-3-methylphenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid (example BJ) and 2-cyclopropyl-4-thiazolemethanamine (CAN 1083299-53-9) as starting materials; LC-MS (UV peak area/ESI) 95.4%, 482.09 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08729105B2
Source datasetuspto-grants-2014_05
ORD IDord-623dd26a80904c55b134df36712e197d
Source noteuspto-grants-2014_05