(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → 5-(3,4-difluorophenyl)-6-(2-methoxyethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

HRID 1026088Notes

Reaction equation

HRID 1026088 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]([O:18][CH2:19][CH2:20][O:21][CH3:22])=[N:11][CH:12]=[C:13]([CH:17]=2)[C:14]([OH:16])=O)[CH:5]=[CH:6][C:7]=1[F:8].[F:23][C:24]([F:33])([F:32])[C:25]1[N:29]=[C:28]([CH2:30][NH2:31])[O:27][N:26]=1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]([O:18][CH2:19][CH2:20][O:21][CH3:22])=[N:11][CH:12]=[C:13]([CH:17]=2)[C:14]([NH:31][CH2:30][C:28]2[O:27][N:26]=[C:25]([C:24]([F:33])([F:32])[F:23])[N:29]=2)=[O:16])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 55263061(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamineHCID 66678797HCID 66678797, compound

Product 1

HCID 569295605-(3,4-difluorophenyl)-6-(2-methoxyethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(3,4-difluorophenyl)-6-(2-methoxyethoxy)-nicotinic acid (example CE) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; LC-MS (UV peak area/ESI) 87.6%, 459.1 (M+H)+.

Sources & evidence

ORD record
ord-2db175d1d63c414787bb2bbba4e925cc
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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