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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1026088Generated: November 2, 2026

(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → 5-(3,4-difluorophenyl)-6-(2-methoxyethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

https://huagongshe.com/reaction/1026088

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamineHCID 55263061—
ReactantHCID 66678797HCID 66678797—
Product5-(3,4-difluorophenyl)-6-(2-methoxyethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamideHCID 56929560—

Reaction Steps

The title compound was synthesized in analogy to Example 1 using 5-(3,4-difluorophenyl)-6-(2-methoxyethoxy)-nicotinic acid (example CE) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; LC-MS (UV peak area/ESI) 87.6%, 459.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08729105B2
Source datasetuspto-grants-2014_05
ORD IDord-2db175d1d63c414787bb2bbba4e925cc
Source noteuspto-grants-2014_05