3-Methoxy-5-isoxazolemethanamine → 5-(3,4-difluorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

HRID 1026091Notes

Reaction equation

HRID 1026091 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[N:11][CH:12]=[C:13]([CH:17]=2)[C:14]([OH:16])=O)[CH:5]=[CH:6][C:7]=1[F:8].[CH3:24][O:25][C:26]1[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[N:11][CH:12]=[C:13]([CH:17]=2)[C:14]([NH:32][CH2:31][C:29]2[O:28][N:27]=[C:26]([O:25][CH3:24])[CH:30]=2)=[O:16])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 27632273-Methoxy-5-isoxazolemethanamineHCID 666788705-(3,4-Difluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 569295635-(3,4-difluorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(3,4-difluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid (example BX) and 3-methoxy-5-isoxazolemethanamine (CAN 2763-94-2) as starting materials; LC-MS (UV peak area/ESI) 84%, 407.9815 (M+H)+.

Sources & evidence

ORD record
ord-faa3a4f870f2466a8564ce6a7bb70769
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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