HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxy-5-isoxazolemethanamine → 5-(3,4-difluorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxy-5-isoxazolemethanamine | HCID 2763227 | — |
| Reactant | 5-(3,4-Difluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid | HCID 66678870 | — |
| Product | 5-(3,4-difluorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide | HCID 56929563 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1 using 5-(3,4-difluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid (example BX) and 3-methoxy-5-isoxazolemethanamine (CAN 2763-94-2) as starting materials; LC-MS (UV peak area/ESI) 84%, 407.9815 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-faa3a4f870f2466a8564ce6a7bb70769 |
| Source note | uspto-grants-2014_05 |