反应详情

A suspension of 4-amino-3-nitrobenzamidine monohydrochloride (15 g, 69 mmol) and Pearlman's catalyst [Pd(OH)2, 1.0 g, 7.12 mmol) in methanol (200 mL) was shaken under hydrogen atmosphere 50 psi for 1.5 h. The suspension was filtered through Celite and the filtrate was added dropwise to anhydrous diethyl ether (400 mL) to precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid.

1. filtrationThe suspension was filtered through Celite
2. additionthe filtrate was added dropwise to anhydrous diethyl ether (400 mL)
3. customto precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid