Benzyl Bromide → HCID 67778233, compound

HRID 1026223Notes

Reaction equation

HRID 1026223 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH3:21])[CH2:10][O:11][C:12]1[CH:16]=[C:15]([C:17]([O:19][CH3:20])=[O:18])[NH:14][N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:23]([N:14]1[C:15]([C:17]([O:19][CH3:20])=[O:18])=[CH:16][C:12]([O:11][CH2:10][C@@H:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH3:21])=[N:13]1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 67778799HCID 67778799, compound

Product 1

HCID 67778233HCID 67778233, compound

Procedure

Using methyl 3-({(2S)-2-[(tert-butoxycarbonyl)amino]propyl}oxy)-1H-pyrazole-5-carboxylate and (bromomethyl)benzene, and in the same manner as in Example 1, step A (reaction temperature was room temperature), the title compound was obtained.

Workup

  1. customin the same manner as in Example 1, step A (reaction temperature was room temperature)

Sources & evidence

ORD record
ord-a11648d3e3064dcb837c71988978b74d
Source dataset
uspto-grants-2014_05
Patent number
US08729102B2

Reaction notes

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