HCID 86666274, compound → HCID 86666275, compound

HRID 1026250Notes

Reaction equation

HRID 1026250 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[N+:20]([O-])=O)[O:5][CH2:6][C@@H:7]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH3:8]>[Pd].C(O)C>[NH2:20][C:19]1[CH:18]=[CH:17][C:4]([O:5][CH2:6][C@@H:7]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:13])[CH3:14])[CH3:8])=[CH:3][C:2]=1[F:1]

Participants

4

Reactant 1

HCID 86666274HCID 86666274, compound

Product 1

HCID 86666275HCID 86666275, compoundYield 93.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Under a hydrogen atmosphere, a mixture of tert-butyl [(1S)-2-(3-fluoro-4-nitrophenoxy)-1-methylethyl]carbamate (10.2 g), 10% palladium/carbon (containing water (50%), 500 mg) and ethanol (150 mL) was stirred at room temperature for 1 hr. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure to give the title compound as a brown solid (8.64 g).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4e2df1500b424d01ab594eed2178627d
Source dataset
uspto-grants-2014_05
Patent number
US08729102B2

Reaction notes

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