Triethyl phosphite → HCID 67777907, compound

HRID 1026255Notes

Reaction equation

[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([N:12]=[N:13][C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)=[C:8]([N+:21]([O-])=O)[CH:7]=2)[CH2:3][CH2:2]1.P(OCC)(OCC)OCC>>[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]3=[N:12][N:13]([C:14]4[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=4)[N:21]=[C:8]3[CH:7]=2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 31215Triethyl phosphite

HCID 136372363HCID 136372363, compound

Product 1

HCID 67777907HCID 67777907, compound

Conditions

Temperature: 140 °C

Procedure

A mixture of 4-{[4-(cyclopropylmethoxy)-2-nitrophenyl]diazenyl}phenol and triethyl phosphite (4 mL) was stirred at 140° C. overnight. The reaction mixture was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound as a yellow solid (103 mg).

Workup

customThe reaction mixture was purified by silica gel column chromatography (hexane/ethyl acetate)

Sources & evidence

ORD record: ord-705e89c5c32d4f2f9201dbe36ceaa156
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729102B2

Reaction notes

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