1132843-09-4 → tert-butyl {(1S)-2-[(6-{6-[(3,3-difluorocyclobutyl)methoxy]-1,3-benzoxazol-2-yl}pyridin-3-yl)oxy]-1-methylethyl}carbamate

HRID 1026261Notes

Reaction equation

HRID 1026261 reaction equation
[OH:1][C:2]1[CH:28]=[CH:27][C:5]2[N:6]=[C:7]([C:9]3[N:14]=[CH:13][C:12]([O:15][CH2:16][C@@H:17]([NH:19][C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23])[CH3:18])=[CH:11][CH:10]=3)[O:8][C:4]=2[CH:3]=1.CS(O[CH2:34][CH:35]1[CH2:38][C:37]([F:40])([F:39])[CH2:36]1)(=O)=O>>[F:39][C:37]1([F:40])[CH2:38][CH:35]([CH2:34][O:1][C:2]2[CH:28]=[CH:27][C:5]3[N:6]=[C:7]([C:9]4[N:14]=[CH:13][C:12]([O:15][CH2:16][C@@H:17]([NH:19][C:20](=[O:26])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH3:18])=[CH:11][CH:10]=4)[O:8][C:4]=3[CH:3]=2)[CH2:36]1

Participants

3

Reactant 2

HCID 582234121132843-09-4HCID 136372364tert-butyl [(1S)-2-{[6-(6-hydroxy-1,3-benzoxazol-2-yl)pyridin-3-yl]oxy}-1-methylethyl]carbamate

Product 1

HCID 86666283tert-butyl {(1S)-2-[(6-{6-[(3,3-difluorocyclobutyl)methoxy]-1,3-benzoxazol-2-yl}pyridin-3-yl)oxy]-1-methylethyl}carbamate

Procedure

Using tert-butyl [(1S)-2-{[6-(6-hydroxy-1,3-benzoxazol-2-yl)pyridin-3-yl]oxy}-1-methylethyl]carbamate and (3,3-difluorocyclobutyl)methyl methanesulfonate, and in the same manner as in Example 2, step E, the title compound was obtained.

Sources & evidence

ORD record
ord-9e15a53a5fed449cbe5809a145d973cf
Source dataset
uspto-grants-2014_05
Patent number
US08729102B2

Reaction notes

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