反应详情

To a solution of 2-ethylhexyl 3-{[5-(benzyloxy)-2-nitrophenyl]sulfanyl}propanoate (3.60 g) and 6M hydrochloric acid (2.69 mL) in ethanol (46 mL) was added reduced iron (4.51 g), and the mixture was heated under reflux for 3 hr. The insoluble material was removed by filtration, and the solvent of the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound as a dark red liquid (2.38 g).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hr
3. customThe insoluble material was removed by filtration
4. customthe solvent of the filtrate was evaporated under reduced pressure
5. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate)