4-Aminobenzene-1,3-diol hydrochloride → tert-butyl [(1S)-2-({5-[(2,4-dihydroxyphenyl)carbamoyl]isoxazol-3-yl}oxy)-1-methylethyl]carbamate

HRID 1026278Notes

Reaction equation

HRID 1026278 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH3:20])[CH2:10][O:11][C:12]1[CH:16]=[C:15]([C:17]([OH:19])=O)[O:14][N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[NH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][C:24]=1[OH:30]>>[OH:30][C:24]1[CH:25]=[C:26]([OH:29])[CH:27]=[CH:28][C:23]=1[NH:22][C:17]([C:15]1[O:14][N:13]=[C:12]([O:11][CH2:10][C@@H:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4])[CH3:20])[CH:16]=1)=[O:19]

Participants

3

Reactant 2

HCID 134088224-Aminobenzene-1,3-diol hydrochlorideHCID 677777153-({(2S)-2-[(tert-butoxycarbonyl)amino]propyl}oxy)isoxazole-5-carboxylic acid

Product 1

HCID 86666289tert-butyl [(1S)-2-({5-[(2,4-dihydroxyphenyl)carbamoyl]isoxazol-3-yl}oxy)-1-methylethyl]carbamate

Procedure

Using 3-({(2S)-2-[(tert-butoxycarbonyl)amino]propyl}oxy)isoxazole-5-carboxylic acid and 4-aminobenzene-1,3-diol hydrochloride, and in the same manner as in Example 2, step C, the title compound was obtained.

Sources & evidence

ORD record
ord-55cb9b35daa2485480f75b3b9702c892
Source dataset
uspto-grants-2014_05
Patent number
US08729102B2

Reaction notes

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