Iodoethane → tert-butyl [(1S)-2-{[5-(5-ethoxy-1,3-benzoxazol-2-yl)isoxazol-3-yl]oxy}-1-methylethyl]carbamate

HRID 1026285Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[O:14][N:13]=[C:12]([O:15][CH2:16][C@@H:17]([NH:19][C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23])[CH3:18])[CH:11]=3)=[N:7][C:6]=2[CH:27]=1.[CH2:28](I)[CH3:29]>>[CH2:28]([O:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[O:14][N:13]=[C:12]([O:15][CH2:16][C@@H:17]([NH:19][C:20](=[O:26])[O:21][C:22]([CH3:23])([CH3:25])[CH3:24])[CH3:18])[CH:11]=3)=[N:7][C:6]=2[CH:27]=1)[CH3:29]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 86666264tert-butyl [(1S)-2-{[5-(5-hydroxy-1,3-benzoxazol-2-yl)isoxazol-3-yl]oxy}-1-methylethyl]carbamate

Product 1

HCID 123917271tert-butyl [(1S)-2-{[5-(5-ethoxy-1,3-benzoxazol-2-yl)isoxazol-3-yl]oxy}-1-methylethyl]carbamate

Procedure

Using tert-butyl [(1S)-2-{[5-(5-hydroxy-1,3-benzoxazol-2-yl)isoxazol-3-yl]oxy}-1-methylethyl]carbamate and ethyl iodide, and in the same manner as in Example 2, step E, the title compound was obtained.

Sources & evidence

ORD record: ord-df8e1ca5042d484c8ad59694ee6d0ffa
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729102B2

Reaction notes

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