反应详情

Into a 3 L three-neck flask equipped with a stirrer, and a cooling tube, chlorosulfonic acid (233.0 g, 2 mol) was added, and then 2,5-dichlorobenzophenone (100.4 g, 400 mmol) was added. The mixture was reacted for 8 hours using an oil bath at 100° C. After a predetermined period of time, the reaction liquid was slowly poured into broken ice (1000 g), and extraction using ethyl acetate was carried out. An organic layer was washed with a saline solution, and was dried with magnesium sulfate. Then, the ethyl acetate was distilled away, thereby obtaining a crude crystal of pale yellow (3-(2,5-dichlorobenzoyl)benzene sulfonic acid chloride). The crude crystal was employed at the subsequent step without purification.

1. customInto a 3 L three-neck flask equipped with a stirrer, and a cooling tube
2. customThe mixture was reacted for 8 hours
3. customat 100° C
4. waitAfter a predetermined period of time
5. customthe reaction liquid
6. washAn organic layer was washed with a saline solution
7. dry with materialwas dried with magnesium sulfate
8. distillationThen, the ethyl acetate was distilled away