4,6-Dichloro-5-(2-chloro-5-methoxy-phenoxy)-pyrimidine → Benzylsulfamic acid [6-chloro-5-(2-chloro-5-methoxy-phenoxy)-pyrimidin-4-yl]-amide

HRID 10265Notes

Reaction equation

HRID 10265 reaction equation
Cl[C:2]1[C:7]([O:8][C:9]2[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:10]=2[Cl:17])=[C:6]([Cl:18])[N:5]=[CH:4][N:3]=1.[K].[CH2:20]([NH:27][S:28](=[O:31])(=[O:30])[NH2:29])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[Cl:18][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:29][S:28](=[O:30])(=[O:31])[NH:27][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:7]=1[O:8][C:9]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:10]=1[Cl:17]

Participants

3

Reactant 2

HCID 219795664,6-Dichloro-5-(2-chloro-5-methoxy-phenoxy)-pyrimidineHCID 68727905Benzylsulfamic acid amide potassium salt

Product 1

HCID 21041375Benzylsulfamic acid [6-chloro-5-(2-chloro-5-methoxy-phenoxy)-pyrimidin-4-yl]-amideYield 47%

Procedure

Benzylsulfamic acid [6-chloro-5-(2-chloro-5-methoxy-phenoxy)-pyrimidin-4-yl]-amide (0.7 g) was prepared from 4,6-dichloro-5-(2-chloro-5-methoxy-phenoxy)-pyrimidine (1 g) and benzylsulfamic acid amide potassium salt (1.21 g) according to the procedure described in Referential Example 15. LC-MS: tR=5.13; [M+H]+=456.91.

Sources & evidence

ORD record
ord-829e83a9265c4f86b928d2636b829e73
Source dataset
uspto-grants-2006_08
Patent number
US07094781B2

Reaction notes

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