HCID 178430719, compound → HCID 178430713, compound

HRID 1026544Notes

Reaction equation

HRID 1026544 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([N+:9]([O-])=O)[C:5]([OH:8])=[N:6][CH:7]=1>O1CCCC1.CO.[C].[Pd]>[NH2:9][C:4]1[C:5]([OH:8])=[N:6][CH:7]=[C:2]([CH3:1])[CH:3]=1

Participants

5

Reactant 1

HCID 178430719HCID 178430719, compound

Product 1

HCID 178430713HCID 178430713, compoundYield 100.1%

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

At room temperature, to a mixed solvent solution of 5-methyl-3-nitropyridin-2-ol (5.0 g) in tetrahydrofuran (200 ml) and methanol (200 ml) was added 10% palladium carbon (0.5 g), followed by stirring for 24 hours under a hydrogen atmosphere. The reaction solution was filtered through Celite, and then the filtrate was concentrated under reduced pressure to afford 3-amino-5-methylpyridin-2-ol (4.03 g).

Workup

  1. filtrationThe reaction solution was filtered through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-578374b537694e4eb7bab951793381ef
Source dataset
uspto-grants-2014_05
Patent number
US08729095B2

Reaction notes

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