反应详情

温度

150 °C

2-Cyano-3-(2,6-dichlorophenyl)propanoic acid (447 mmol, 109 g) was dissolved in DMA (179 ml) and heated for 2 hours at 150° C. After cooling, the reaction mixture was poured into water and extracted with ether. The organic layer was washed with a saturated solution of sodium hydrogen carbonate and then with a saturated solution of sodium chloride. The organic phase was dried over sodium sulfate and concentrated under reduced pressure to afford 3-(2,6-dichlorophenyl)propanenitrile (94% yield, 83.8 g).

1. temperatureAfter cooling
2. extractionextracted with ether
3. washThe organic layer was washed with a saturated solution of sodium hydrogen carbonate
4. dry with materialThe organic phase was dried over sodium sulfate
5. concentrationconcentrated under reduced pressure