Piperazine → HCID 11465078, compound

HRID 1026680Notes

Reaction equation

HRID 1026680 reaction equation
[O:1]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]4=[O:25])=[CH:11][C:10]=3[F:26])[CH2:5][CH2:4]2)[CH2:2]1.[NH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>CO>[N:27]1([CH2:2][C:3]2([OH:1])[CH2:4][CH2:5][N:6]([C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]4=[O:25])=[CH:11][C:10]=3[F:26])[CH2:7][CH2:8]2)[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 11382912HCID 11382912, compound

Product 1

HCID 11465078HCID 11465078, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared by reacting (S)—N-{3-[4-(1-oxa-6-aza-spiro[2.5]oct-6-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (1.37 mmol) with piperazine (2.06 mmol) in methanol (10 ml) at a temperature 25° C. for 14 hours and by purifying the compound by silica gel column chromatography in 80% yield.

Workup

  1. customat a temperature 25° C.
  2. customfor 14 hours
  3. customby purifying the compound by silica gel column chromatography in 80% yield

Sources & evidence

ORD record
ord-d46f75cbc3d742a28317607c9f39440e
Source dataset
uspto-grants-2014_05
Patent number
US08729269B2

Reaction notes

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