Sodium Cyanide → HCID 11156399, compound

HRID 1026693Notes

Reaction equation

HRID 1026693 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=[O:23])[CH3:22])[O:16][C:15]3=[O:24])=[CH:10][C:9]=2[F:25])[CH2:4][CH2:3]1.[C-:26]#[N:27].[Na+].[F:29][C:30]1[C:36]([F:37])=[C:35]([F:38])[CH:34]=[CH:33][C:31]=1[NH2:32]>>[F:29][C:30]1[C:36]([F:37])=[C:35]([F:38])[CH:34]=[CH:33][C:31]=1[NH:32][C:2]1([C:26]#[N:27])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=[O:23])[CH3:22])[O:16][C:15]3=[O:24])=[CH:10][C:9]=2[F:25])[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 8929Sodium CyanideHCID 774682,3,4-TrifluoroanilineHCID 54375226N-[(5S)-3-[3-fluoro-4-(4-oxopiperidinyl)phenyl]-2-oxo-5-oxazolidinyl]methylacetamide

Product 1

HCID 11156399HCID 11156399, compoundYield 68%

Procedure

By using procedure as described in Example 45 and by reacting (S)—N-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide with sodium cyanide and 2,3,4-trifluoroaniline the compound was obtained in 68% yield.

Workup

  1. customwas obtained in 68% yield

Sources & evidence

ORD record
ord-fc95e209a56f4768aed8d9da2705b6ee
Source dataset
uspto-grants-2014_05
Patent number
US08729269B2

Reaction notes

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