Sodium borohydride → HCID 60133465, compound

HRID 1026732Notes

Reaction equation

HRID 1026732 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=[O:23])[CH3:22])[O:16][C:15]3=[O:24])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[BH4-].[Na+]>CO>[OH:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:9]=[CH:10][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=[O:23])[CH3:22])[O:16][C:15]3=[O:24])=[CH:12][CH:13]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 59754123HCID 59754123, compound

Product 1

HCID 60133465HCID 60133465, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared by reacting (S)—N-{3-[4-(4-oxo-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (1.0 mmol), with sodiumborohydride (1.2 mmol)) methanol (10 ml) at a temperature 0-25° C. for 2 hours in 85% yield.

Sources & evidence

ORD record
ord-33be73423ca24eba8e0dcd5bcddbc651
Source dataset
uspto-grants-2014_05
Patent number
US08729269B2

Reaction notes

Loading…