Potassium Carbonate → HCID 86690467, compound

HRID 1026740Notes

Reaction equation

HRID 1026740 reaction equation
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[C:8]([Br:13])[N:7]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[Br:13][C:8]1[N:7]=[C:6]([CH2:5][OH:4])[CH:11]=[CH:10][C:9]=1[F:12]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86690466HCID 86690466, compound

Product 1

HCID 86690467HCID 86690467, compoundYield 107.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (6-bromo-5-fluoropyridin-2-yl)methyl acetate (240 mg) in methanol (2.50 mL) was added an aqueous solution of 1M potasium carbonate (1.64 mL) and the mixture was stirred at room temperature for 20.5 hr. After the solvent was distilled off under reduced pressure, water was added, followed by exraction with chloroform. The organic phase was separated out and the solvent was distilled off under reduced pressure to afford (6-bromo-5-fluoropyridin-2-yl)methanol (215 mg) as the residue.

Workup

  1. distillationAfter the solvent was distilled off under reduced pressure, water
  2. additionwas added
  3. customThe organic phase was separated out
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-48712433a1464a24811d00fea7067f40
Source dataset
uspto-grants-2014_05
Patent number
US08729271B2

Reaction notes

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