Water → HCID 60998602, compound

HRID 1026754Notes

Reaction equation

HRID 1026754 reaction equation
I(C1C=CC=CC=1C(O)=O)(=O)=O.[F:13][C:14]([F:30])([F:29])[O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[S:23][CH:24]=[C:25]([CH2:27][OH:28])[N:26]=2)=[CH:18][CH:17]=1.O>CS(C)=O>[F:30][C:14]([F:13])([F:29])[O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[S:23][CH:24]=[C:25]([CH:27]=[O:28])[N:26]=2)=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 962WaterHCID 1087942-Iodoxybenzoic acidHCID 69184067HCID 69184067, compound

Product 1

HCID 60998602HCID 60998602, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

A solution of 2-iodoxybenzoic acid (441 mg) in dimethylsulfoxide (5 mL) was added to a solution of {2-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-4-yl}methanol (361 mg) in dimethylsulfoxide (10 mL) and the resulting mixture was stirred at room temperature overnight. After water was added, the mixture was filtered through Celite and then extracted with ethyl acetate. The solvent was distilled off under reduced pressure to afford the title compound (358 mg) as the residue.

Workup

  1. filtrationthe mixture was filtered through Celite
  2. extractionextracted with ethyl acetate
  3. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-51d3b8a9a8804c08864017e8953ce2a4
Source dataset
uspto-grants-2014_05
Patent number
US08729271B2

Reaction notes

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