Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | HCID 86690497 | HCID 86690497 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86690496 | HCID 86690496 | 9.7% |
Reaction Steps
A mixture of N-{2-[({amino[4-(trifluoromethoxy)phenyl]methylidene}amino)oxy]-2-oxoethyl}-N-cyclobutyl-1-methyl-1H-imidazole-4-carboxamide (75 mg), acetic acid (0.5 mL) and dimethylformamide (0.5 mL) was stirred while heating at 120° C. for 2 hr. After the solvent was distilled off under reduced pressure, the resulting residue was purified by HPLC to afford the title compound (7 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08729271B2 |
|---|
| Source dataset | uspto-grants-2014_05 |
|---|
| ORD ID | ord-ad271569084d4586859898bd485bd27e |
|---|
| Source note | uspto-grants-2014_05 |
|---|