Acetic Acid → HCID 86690496, compound

HRID 1026768Notes

Reaction equation

HRID 1026768 reaction equation
[NH2:1][C:2](=[N:14][O:15][C:16](=O)[CH2:17][N:18]([CH:27]1[CH2:30][CH2:29][CH2:28]1)[C:19]([C:21]1[N:22]=[CH:23][N:24]([CH3:26])[CH:25]=1)=[O:20])[C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]([F:13])([F:12])[F:11])=[CH:5][CH:4]=1.C(O)(=O)C>CN(C)C=O>[CH:27]1([N:18]([CH2:17][C:16]2[O:15][N:14]=[C:2]([C:3]3[CH:8]=[CH:7][C:6]([O:9][C:10]([F:13])([F:12])[F:11])=[CH:5][CH:4]=3)[N:1]=2)[C:19]([C:21]2[N:22]=[CH:23][N:24]([CH3:26])[CH:25]=2)=[O:20])[CH2:30][CH2:29][CH2:28]1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 86690497HCID 86690497, compound

Product 1

HCID 86690496HCID 86690496, compoundYield 9.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of N-{2-[({amino[4-(trifluoromethoxy)phenyl]methylidene}amino)oxy]-2-oxoethyl}-N-cyclobutyl-1-methyl-1H-imidazole-4-carboxamide (75 mg), acetic acid (0.5 mL) and dimethylformamide (0.5 mL) was stirred while heating at 120° C. for 2 hr. After the solvent was distilled off under reduced pressure, the resulting residue was purified by HPLC to afford the title compound (7 mg).

Workup

  1. distillationAfter the solvent was distilled off under reduced pressure
  2. customthe resulting residue was purified by HPLC

Sources & evidence

ORD record
ord-ad271569084d4586859898bd485bd27e
Source dataset
uspto-grants-2014_05
Patent number
US08729271B2

Reaction notes

Loading…