Valproic Acid → Divalproex sodium [USAN:USP]

Participants

Reaction Steps

In a 3-L round-bottomed flask was placed valproic acid (144 g, 1 mole) and 40% NaOH aqueous solution (50 g, 0.5 mole). The resulting solution was then put on a rotavaper, applied vacuum, and heated up slowly (e.g., water bath temperature from room temperature to 95° C.) to remove the water. Upon completion of the water removals the reaction mixture was allowed to cool down to room temperature to obtain divalproex sodium (154 g, 100%).

Provenance & Evidence