Valproic Acid → Divalproex sodium [USAN:USP]

HRID 1026770Notes

Reaction equation

HRID 1026770 reaction equation
[C:1]([OH:10])(=[O:9])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].[OH-].[Na+:12]>O>[CH3:5][CH2:4][CH2:3][CH:2]([C:1]([OH:10])=[O:9])[CH2:6][CH2:7][CH3:8].[CH3:5][CH2:4][CH2:3][CH:2]([C:1]([O-:10])=[O:9])[CH2:6][CH2:7][CH3:8].[Na+:12]

Participants

4

Reactant 2

HCID 3121Valproic AcidHCID 14798Sodium Hydroxide

Product 1

HCID 23663956Divalproex sodium [USAN:USP]Yield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a 3-L round-bottomed flask was placed valproic acid (144 g, 1 mole) and 40% NaOH aqueous solution (50 g, 0.5 mole). The resulting solution was then put on a rotavaper, applied vacuum, and heated up slowly (e.g., water bath temperature from room temperature to 95° C.) to remove the water. Upon completion of the water removals the reaction mixture was allowed to cool down to room temperature to obtain divalproex sodium (154 g, 100%).

Workup

  1. customIn a 3-L round-bottomed flask was placed
  2. customto remove the water

Sources & evidence

ORD record
ord-53596497a2a342abb1c1e99837bf6ab3
Source dataset
uspto-grants-2014_05
Patent number
US08729300B2

Reaction notes

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