Valproic Acid → Sodium valproate

HRID 1026771Notes

Reaction equation

HRID 1026771 reaction equation
[C:1]([OH:10])(=[O:9])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].[OH-].[Na+:12]>O>[C:1]([O-:10])(=[O:9])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].[Na+:12]

Participants

4

Reactant 2

HCID 3121Valproic AcidHCID 14798Sodium Hydroxide

Product 1

HCID 16760703Sodium valproateYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a 3-L round-bottomed flask was placed valproic acid (144 g, 1 mole) and 40% NaOH aqueous solution (100 g, 1 mole). The resulting solution was then put on a rotavaper, applied vacuum, and heated up slowly (e.g., water bath temperature from room temperature to 95° C.) to remove the water. Upon completion of the water removal, the reaction mixture was allowed to cool down to room temperature to obtain sodium valproate (166 g, 100%).

Workup

  1. customIn a 3-L round-bottomed flask was placed
  2. customto remove the water
  3. customUpon completion of the water removal

Sources & evidence

ORD record
ord-aca6e1f5cafb4e6fbe530f60775415ac
Source dataset
uspto-grants-2014_05
Patent number
US08729300B2

Reaction notes

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