4-(2-Thienyl)piperidine hydrochloride → 3-Bromo-7-benzylamino-6-[4-(thiophen-2-yl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine
Reaction equation
[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([Br:18])=[C:13]2[N:12]=[CH:11][C:10]=1[C:19]([OH:21])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[S:23]1[CH:27]=[CH:26][CH:25]=[C:24]1[CH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[Br:18][C:17]1[CH:16]=[N:15][N:14]2[C:9]([NH:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[C:10]([C:19]([N:31]3[CH2:32][CH2:33][CH:28]([C:24]4[S:23][CH:27]=[CH:26][CH:25]=4)[CH2:29][CH2:30]3)=[O:21])[CH:11]=[N:12][C:13]=12Participants
3
Procedure
In the same manner as in Example 21, step 5 and using 7-benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.10 g, 0.29 mmol) obtained in Example 22, step 3 and 4-(thiophen-2-yl)piperidine hydrochloride (0.07 g, 0.35 mmol), the title compound (0.14 g, 99%) was obtained.
Sources & evidence
- ORD record
- ord-7ce318d6eeb64584bbadc66adee69f3f
- Source dataset
- uspto-grants-2014_05
- Patent number
- US08729264B2
Reaction notes
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