3,5-Dimethylisoxazole-4-sulfonamide → N-[7-(2-Methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl]-3,5-dimethylisoxazole-4-sulfonamide

HRID 1026953Notes

Reaction equation

HRID 1026953 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([OH:20])=O)=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:28][CH2:27][CH:26]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:25][CH2:24]1)=[O:22].[CH3:35][C:36]1[C:40]([S:41]([NH2:44])(=[O:43])=[O:42])=[C:39]([CH3:45])[O:38][N:37]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([NH:44][S:41]([C:40]3[C:36]([CH3:35])=[N:37][O:38][C:39]=3[CH3:45])(=[O:42])=[O:43])=[O:20])=[C:13]2[N:12]=[CH:11][C:10]=1[C:21]([N:23]1[CH2:24][CH2:25][CH:26]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:27][CH2:28]1)=[O:22]

Participants

3

Reactant 2

HCID 49623033,5-Dimethylisoxazole-4-sulfonamideHCID 675406217-(2-Methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 67540876N-[7-(2-Methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl]-3,5-dimethylisoxazole-4-sulfonamideYield 66%

Procedure

In the same manner as in Example 1, step 6 and using 7-(2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.08 g, 0.18 mmol) obtained in Example 39, step 2 and 3,5-dimethylisoxazole-4-sulfonamide (0.16 g, 0.88 mmol), the title compound (0.07 g, 66%) was obtained.

Sources & evidence

ORD record
ord-6f56266cf75b449584d64c537808a84a
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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