2-Fluoro-5-methylaniline → HCID 67539989, compound

HRID 1026997Notes

Reaction equation

HRID 1026997 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[CH2:20][CH2:19]1)=[O:17].[F:31][C:32]1[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][C:33]=1[NH2:34]>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:34][C:33]3[CH:35]=[C:36]([CH3:39])[CH:37]=[CH:38][C:32]=3[F:31])=[C:3]([C:16]([N:18]3[CH2:23][CH2:22][CH:21]([C:24]4[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=4)[CH2:20][CH2:19]3)=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

Participants

3

Reactant 2

HCID 2629702-Fluoro-5-methylanilineHCID 86646293HCID 86646293, compound

Product 1

HCID 67539989HCID 67539989, compoundYield 99.9%

Procedure

In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine (0.090 g, 0.21 mmol) obtained in step 2 and 2-fluoro-5-methylaniline (0.053 g, 0.42 mmol), the title compound (0.109 g, 99%) was obtained.

Sources & evidence

ORD record
ord-957d7f7c02814f1795e9f891657916c8
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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