Piperidine, 4-(2-naphthalenyl)-, hydrochloride (1:1) → 3-Ethoxycarbonyl-7-(2-fluoro-5-methylphenylamino)-6-[4-(2-naphthyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([NH:15][C:16]3[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=3[F:23])=[C:13]([C:24]([OH:26])=O)[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].Cl.[CH:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=[CH:30][C:29]=1[CH:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([NH:15][C:16]3[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=3[F:23])=[C:13]([C:24]([N:41]3[CH2:42][CH2:43][CH:38]([C:29]4[CH:30]=[CH:31][C:32]5[C:37](=[CH:36][CH:35]=[CH:34][CH:33]=5)[CH:28]=4)[CH2:39][CH2:40]3)=[O:26])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]Participants
3
Reactant 2
Product 1
Procedure
In the same manner as in Example 21, step 5 and using 3-ethoxycarbonyl-7-(2-fluoro-5-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid (120 mg, 0.33 mmol) obtained in Example 90, step 2 and 4-(2-naphthyl)piperidine hydrochloride (WO1997/037979, 100 mg, 0.40 mmol), the title compound (89 mg, 49%) was obtained.
Sources & evidence
- ORD record
- ord-1877f2553f514af0b9bb24524699b5f2
- Source dataset
- uspto-grants-2014_05
- Patent number
- US08729264B2
Reaction notes
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