HRID1027019

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID45073928

4-(Naphthalen-2-yl)piperidine--hydrogen chloride (1/1)

C15H18ClN

结构：CCOC(=O)c1cnn2c(Nc3cc(C)ccc3F)c(C(=O)O)cnc12

HCID67540774

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cnn2c(Nc3cc(C)ccc3F)c(C(=O)N3CCC(c4ccc5ccccc5c4)CC3)cnc12

HCID67540779

未命名化合物

收率 49%

PROCEDURE

实验过程

In the same manner as in Example 21, step 5 and using 3-ethoxycarbonyl-7-(2-fluoro-5-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid (120 mg, 0.33 mmol) obtained in Example 90, step 2 and 4-(2-naphthyl)piperidine hydrochloride (WO1997/037979, 100 mg, 0.40 mmol), the title compound (89 mg, 49%) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1877f2553f514af0b9bb24524699b5f2
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08729264B2
来源说明: uspto-grants-2014_05

反应 SMILES

[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([NH:15][C:16]3[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=3[F:23])=[C:13]([C:24]([OH:26])=O)[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].Cl.[CH:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=[CH:30][C:29]=1[CH:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([NH:15][C:16]3[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=3[F:23])=[C:13]([C:24]([N:41]3[CH2:42][CH2:43][CH:38]([C:29]4[CH:30]=[CH:31][C:32]5[C:37](=[CH:36][CH:35]=[CH:34][CH:33]=5)[CH:28]=4)[CH2:39][CH2:40]3)=[O:26])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]