2,5-Dimethylaniline → HCID 67541263, compound

HRID 1027033Notes

Reaction equation

HRID 1027033 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][N:5]2[C:10](Cl)=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:8]=[N:7][C:6]=12.[CH3:17][C:18]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:19]=1[NH2:20]>>[Br:1][C:2]1[CH:3]=[N:4][N:5]2[C:10]([NH:20][C:19]3[CH:21]=[C:22]([CH3:25])[CH:23]=[CH:24][C:18]=3[CH3:17])=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:8]=[N:7][C:6]=12

Participants

3

Reactant 2

HCID 72592,5-DimethylanilineHCID 57345881Ethyl 3-bromo-7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate

Product 1

HCID 67541263HCID 67541263, compoundYield 68%

Procedure

In the same manner as in Example 1, step 4 and using ethyl 3-bromo-7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate (400 mg, 1.31 mmol) obtained in Example 22, step 1 and 2,5-dimethylaniline (0.19 mL, 1.57 mmol), the title compound (345 mg, 68%) was obtained.

Sources & evidence

ORD record
ord-f57b2c51a69b4800a36f3ba8ef97cb23
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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