4-Fluoro-2-methylaniline → HCID 67540887, compound

HRID 1027038Notes

Reaction equation

HRID 1027038 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][N:5]2[C:10](Cl)=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:8]=[N:7][C:6]=12.[F:17][C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[C:20]([CH3:25])[CH:19]=1>>[Br:1][C:2]1[CH:3]=[N:4][N:5]2[C:10]([NH:22][C:21]3[CH:23]=[CH:24][C:18]([F:17])=[CH:19][C:20]=3[CH3:25])=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:8]=[N:7][C:6]=12

Participants

3

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 57345881Ethyl 3-bromo-7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate

Product 1

HCID 67540887HCID 67540887, compoundYield 99.9%

Procedure

In the same manner as in Example 1, step 4 and using ethyl 3-bromo-7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate (3.5 g, 11.4 mmol) obtained in Example 22, step 1 and 4-fluoro-2-methylaniline (1.53 mL, 22.8 mmol), the title compound (4.48 g, 99%) was obtained.

Sources & evidence

ORD record
ord-20186268401b48af8e3237d0911b42cf
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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