HRID1027056

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)c1cnn2c(Nc3cc(C)ccc3C)c(C(=O)O)cnc12

HCID67540739

未命名化合物

HCID67540763

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cnn2c(Nc3cc(C)ccc3C)c(C(=O)N3CCC4(CC3)C(C)=Cc3ccccc34)cnc12

HCID67540486

未命名化合物

收率 65%

PROCEDURE

实验过程

In the same manner as in Example 21, step 5 and using 7-(2,5-dimethylphenylamino)-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.100 g, 0.282 mmol) obtained in Example 88, step 2 and 2-methylspiro[inden-1,4′-piperidine] (0.062 g, 0.313 mmol), the title compound (0.098 g, 65%) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a9d602fe328644c9bb23ded02ad5a0c8
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08729264B2
来源说明: uspto-grants-2014_05

反应 SMILES

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:14]2[N:13]=[CH:12][C:11]=1[C:24](O)=[O:25].[CH3:27][C:28]1[C:36]2([CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:14]2[N:13]=[CH:12][C:11]=1[C:24]([N:39]1[CH2:40][CH2:41][C:36]2([C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH:29]=[C:28]2[CH3:27])[CH2:37][CH2:38]1)=[O:25]