2-Methylspiro[inden-1,4'-piperidine] → HCID 178469962, compound

HRID 1027058Notes

Reaction equation

HRID 1027058 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([OH:18])=O)[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].[CH3:19][C:20]1[C:28]2([CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([N:31]3[CH2:32][CH2:33][C:28]4([C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[CH:21]=[C:20]4[CH3:19])[CH2:29][CH2:30]3)=[O:18])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 675407632-Methylspiro[inden-1,4'-piperidine]HCID 178469973HCID 178469973, compound

Product 1

HCID 178469962HCID 178469962, compoundYield 77.7%

Procedure

In the same manner as in Example 19, step 3 and using 3-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.533 g, 2.12 mmol) obtained in Example 19, step 2 and 2-methylspiro[inden-1,4′-piperidine] (0.465 g, 2.34 mmol), the title compound (0.712 g, 70%) was obtained.

Sources & evidence

ORD record
ord-ee1a6cbbee8647fa9296063b1e7be346
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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