2-Fluoro-5-methylaniline → HCID 67541230, compound

HRID 1027110Notes

Reaction equation

HRID 1027110 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([N:18]1[CH2:23][CH2:22][C:21]2([C:27]3[CH:28]=[CH:29][CH:30]=[C:31]([F:32])[C:26]=3[O:25][CH2:24]2)[CH2:20][CH2:19]1)=[O:17].[F:33][C:34]1[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][C:35]=1[NH2:41]>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:41][C:35]3[CH:36]=[C:37]([CH3:40])[CH:38]=[CH:39][C:34]=3[F:33])=[C:3]([C:16]([N:18]3[CH2:23][CH2:22][C:21]4([C:27]5[CH:28]=[CH:29][CH:30]=[C:31]([F:32])[C:26]=5[O:25][CH2:24]4)[CH2:20][CH2:19]3)=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

Participants

3

Reactant 2

HCID 2629702-Fluoro-5-methylanilineHCID 86646299HCID 86646299, compound

Product 1

HCID 67541230HCID 67541230, compoundYield 52%

Procedure

In the same manner as in Example 19, step 5 and using 7-chloro-3-ethoxycarbonyl-6-(7-fluoro-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine (0.250 g, 0.546 mmol) obtained in Example 145, step 2 and 2-fluoro-5-methylphenylamine (0.150 mL, 1.37 mmol), the title compound (0.155 g, 52%) was obtained.

Sources & evidence

ORD record
ord-df680001fb294f6eadc508a165146a96
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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