3H-spiro[isobenzofuran-1,4'-piperidin]-3-one hydrochloride → HCID 178469966, compound

HRID 1027122Notes

Reaction equation

HRID 1027122 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([OH:18])=O)[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].Cl.[O:20]=[C:21]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:23]2([CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[O:22]1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([N:26]3[CH2:27][CH2:28][C:23]4([C:29]5[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=5)[C:21](=[O:20])[O:22]4)[CH2:24][CH2:25]3)=[O:18])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 223806313H-spiro[isobenzofuran-1,4'-piperidin]-3-one hydrochlorideHCID 178469973HCID 178469973, compound

Product 1

HCID 178469966HCID 178469966, compoundYield 89%

Procedure

In the same manner as in Example 1, step 2 and using 3-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.436 g, 1.74 mmol) obtained in Example 19, step 2 and 3-oxo-3H-spiro[isobenzofuran-1,4′-piperidine]hydrochloride (Journal of Organic Chemistry, 1976, vol. 15, item 2628, 0.500 g, 2.09 mmol), the title compound (0.680 g, 89%) was obtained.

Sources & evidence

ORD record
ord-5adfb3d9d33d426faabc17d690bee690
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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