3H-spiro(2-benzofuran-1,4'-piperidine) hydrochloride → HCID 67540856, compound

HRID 1027125Notes

Reaction equation

HRID 1027125 reaction equation
[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([Br:18])=[C:13]2[N:12]=[CH:11][C:10]=1[C:19]([OH:21])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH:23]1[CH2:28][CH2:27][C:26]2([C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH2:30][O:29]2)[CH2:25][CH2:24]1>>[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([Br:18])=[C:13]2[N:12]=[CH:11][C:10]=1[C:19]([N:23]1[CH2:28][CH2:27][C:26]2([C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH2:30][O:29]2)[CH2:25][CH2:24]1)=[O:21])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 225093303H-spiro(2-benzofuran-1,4'-piperidine) hydrochlorideHCID 675403633-Bromo-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

Product 1

HCID 67540856HCID 67540856, compoundYield 94%

Procedure

In the same manner as in Example 21, step 5 and using 7-benzylamino-3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.754 g, 2.18 mmol) obtained in Example 22, step 3 and 3H-spiro[isobenzofuran-1,4′-piperidine]hydrochloride (Journal of Organic Chemistry, 1976, vol. 15, item 2628, 0.491 g, 0.218 mmol), the title compound (0.484 g, 94%) was obtained.

Sources & evidence

ORD record
ord-6acacbf54b344122a453d06a5176ed47
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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