HRID1027127

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID23572861

tert-Butyl spiro[indole-3,4'-piperidine]-1(2H)-carboxylate

C17H24N2O2

结构：CCOC(=O)c1cnn2c(NCc3ccccc3)c(C(=O)O)cnc12

HCID67540794

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cnn2c(NCc3ccccc3)c(C(=O)N3CCC4(CC3)CN(C(=O)OC(C)(C)C)c3ccccc34)cnc12

HCID67540824

未命名化合物

收率 79.3%

PROCEDURE

实验过程

In the same manner as in Example 21, step 5 and using 7-benzylamino-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.363 g, 1.07 mmol) obtained in Example 21, step 4 and tert-butyl spiro[indoline-3,4′-piperidine]-1-carboxylate (0.370 g, 1.28 mmmol) obtained in Reference Example 8, the title compound (0.518 g, 79%) was obtained.

WORKUP

后处理

customobtained in Reference Example 8

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0391bfd0e71f41e083001f258de22ecd
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08729264B2
来源说明: uspto-grants-2014_05

反应 SMILES

[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:13]2[N:12]=[CH:11][C:10]=1[C:23](O)=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:26]1[CH2:31][CH2:30][C:29]2([C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[N:33]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:32]2)[CH2:28][CH2:27]1>>[CH2:1]([NH:8][C:9]1[N:14]2[N:15]=[CH:16][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:13]2[N:12]=[CH:11][C:10]=1[C:23]([N:26]1[CH2:27][CH2:28][C:29]2([C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[N:33]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:32]2)[CH2:30][CH2:31]1)=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1