tert-Butyl spiro(indole-3,4'-piperidine)-1(2H)-carboxylate → 7-Benzylamino-6-(1-(tert-butoxycarbonyl)spiro[indoline-3,4'-piperidine]-1'-ylcarbonyl)-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine

Participants

Reaction Steps

In the same manner as in Example 21, step 5 and using 7-benzylamino-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.363 g, 1.07 mmol) obtained in Example 21, step 4 and tert-butyl spiro[indoline-3,4′-piperidine]-1-carboxylate (0.370 g, 1.28 mmmol) obtained in Reference Example 8, the title compound (0.518 g, 79%) was obtained.

Provenance & Evidence