1H-Pyrazole-4-boronic acid → HCID 86710666, compound

HRID 1027256Notes

Reaction equation

HRID 1027256 reaction equation
[NH:1]1[CH:5]=[C:4](B(O)O)[CH:3]=[N:2]1.[Br:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13](I)=[CH:12][C:11]=1[O:18][CH3:19]>>[Br:9][C:10]1[C:11]([O:18][CH3:19])=[CH:12][C:13]([C:4]2[CH:3]=[N:2][NH:1][CH:5]=2)=[C:14]([Cl:16])[CH:15]=1

Participants

3

Reactant 2

HCID 177502781H-Pyrazole-4-boronic acidHCID 509978481-Bromo-5-chloro-4-iodo-2-methoxybenzene

Product 1

HCID 86710666HCID 86710666, compoundYield 72.5%

Procedure

Following standard GENERAL METHOD 1-4 for Suzuki coupling using (1H-pyrazol-4-yl)boronic acid (161 mg, 1.44 mmol) and 1-bromo-5-chloro-4-iodo-2-methoxybenzene (500 mg, 1.44 mmol) afforded 4-(4-bromo-2-chloro-5-methoxyphenyl)-1H-pyrazole (300 mg) MS [M+H+]=286.8.

Sources & evidence

ORD record
ord-77e324daa6d5450c8e583a21d46f6947
Source dataset
uspto-grants-2014_05
Patent number
US08729263B2

Reaction notes

Loading…