Hydrochloric Acid → HCID 86710682, compound

HRID 1027268Notes

Reaction equation

HRID 1027268 reaction equation
[CH:1]([O:4][C:5]1[CH:20]=[CH:19][C:8]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[CH:7][C:6]=1[O:21][CH3:22])([CH3:3])[CH3:2].[ClH:23]>>[ClH:23].[CH:1]([O:4][C:5]1[CH:20]=[CH:19][C:8]([CH2:9][CH2:10][NH2:11])=[CH:7][C:6]=1[O:21][CH3:22])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86710681HCID 86710681, compound

Product 1

HCID 86710682HCID 86710682, compoundYield 99.9%

Procedure

In a 50 mL round bottom flask was combined tert-butyl 4-isopropoxy-3-methoxyphenethylcarbamate (810 mg, 2.62 mmol) and HCl (4M in 1,4-dioxane) (6.5 mL, 26.2 mmol). The suspension was stirred at RT for two hours then concentrated in vacuo to afford 2-(4-isopropoxy-3-methoxyphenyl)ethanamine hydrochloride (643 mg) MS [M+H+]=210.3.

Workup

  1. customIn a 50 mL round bottom flask was combined
  2. concentrationthen concentrated in vacuo

Sources & evidence

ORD record
ord-7cba51670ca643e997eb02b3e43949fd
Source dataset
uspto-grants-2014_05
Patent number
US08729263B2

Reaction notes

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