反应详情

温度

80 °C

To a solution of [4-(4′-chloro-4-methylbiphenyl-3-yl)-3,5-dioxocyclohexyl]-acetaldehyde (0.080 g, 0.23 mmol) and propane-1,3-diol (0.021 g, 0.27 mmol) in anhydrous toluene (4 ml) is added a single crystal of para-toluenesulfonic acid and the mixture is stirred at 80° C. for 45 minutes. After cooling to room temperature the solution is concentrated in vacuo to afford a crude product which is purified by flash column chromatography on silica (ethyl acetate eluant) to afford 2-(4′-chloro-4-methylbiphenyl-3-yl)-5-[1,3]dioxan-2-ylmethylcyclohexane-1,3-dione as a white foam.

1. temperatureAfter cooling to room temperature the solution
2. concentrationis concentrated in vacuo
3. customto afford a crude product which
4. customis purified by flash column chromatography on silica (ethyl acetate eluant)