反应详情

4-Allyl-tetrahydro-pyran-4-carboxylic acid methyl ester (11 g, 59.78 mmol) was dissolved in iPrOH (300 mL). To this was added a aqueous solution of NaIO4 (28 g, 130.4 mmol, 2.18 equiv.) in water (300 mL), followed by addition of OsO4 (50 mg, crystals, in one portion) at rt. The solution was stirred with a mechanical stirrer at rt (water bath). After 30 min, milky cloudy mixture was formed. Stirring was continued for an additional period of 4 h. TLC (1% MeOH in DCM, and 5% MeOH in DCM) did not detect the SM. An aliquot was taken, dissolved in CDCl3 and 1H NMR was run, which showed no alkene peak in the sample, and thus the reaction was judged to be complete. The reaction mixture was poured into ice water (200 mL) and EtOAc (200 mL). The two layers were separated and the aqueous layer was extracted with EtOAc (5×50 mL). More water was added to dissolve the solid to result in a clear solution. The combined extracts were washed with brine, and concentrated to dryness to get a liquid product. The liquid product was then subject to a distillation under reduced pressure to remove isopropanol. The remaining liquid was purified on a 80 g silica gel column, eluted with MeOH in DCM: 0% 0-5 min; 5-10% 5-25 min. 10-12% 25-60 min. Note: the product is not UV active. Anisaldehyde visualization was used. The product fractions were collected and concentrated to yield a liquid 6.6 g (60% yield) of the title compound.

1. custommilky cloudy mixture was formed
2. waitwas continued for an additional period of 4 h
3. dissolutiondissolved in CDCl3
4. customThe two layers were separated
5. extractionthe aqueous layer was extracted with EtOAc (5×50 mL)
6. additionMore water was added
7. dissolutionto dissolve the solid
8. customto result in a clear solution
9. washThe combined extracts were washed with brine
10. concentrationconcentrated to dryness
11. customto get a liquid product
12. distillationThe liquid product was then subject to a distillation under reduced pressure
13. customto remove isopropanol
14. customThe remaining liquid was purified on a 80 g silica gel column
15. washeluted with MeOH in DCM
16. custom0% 0-5 min
17. custom5-10% 5-25 min
18. custom10-12% 25-60 min
19. customThe product fractions were collected
20. concentrationconcentrated