反应详情

2-{2-Fluoro-4-[4-((S)-2-methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester was dissolved in 0.5 mL of methanol and cooled to ice-water bath. To this solution was added 0.5 mL of 4M HCl in dioxane (excess). The clear solution was stirred at r.t. overnight. The solvent was evaporated and the residue was further dried under reduced pressure to obtain the title compound as a gummy semi-solid.

1. temperaturecooled to ice-water bath
2. customThe solvent was evaporated
3. customthe residue was further dried under reduced pressure