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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1027433Generated: October 31, 2026

Hydrochloric Acid → 2-[4-(4-Azetidin-1-yl-cyclohexyl)-2-fluoro-phenyl]-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

https://huagongshe.com/reaction/1027433

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant2-[4-(4-Azetidin-1-yl-cyclohexyl)-2-fluoro-phenyl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl esterHCID 54591844—
Solvent1,4-DioxaneHCID 31275—
Product2-[4-(4-Azetidin-1-yl-cyclohexyl)-2-fluoro-phenyl]-2,8-diaza-spiro[4.5]decan-1-one hydrochlorideHCID 67479224—

Reaction Steps

The title compound was prepared in the same manner as Example 17 by using hydrochloric acid in dioxane to hydrolyze 2-[4-(4-azetidin-1-yl-cyclohexyl)-2-fluoro-phenyl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08735385B2
Source datasetuspto-grants-2014_05
ORD IDord-466ae1a1e1394e1b83347efc44bcbb35
Source noteuspto-grants-2014_05