Hydrochloric Acid → 2-[4-(4-Azetidin-1-yl-cyclohexyl)-2-fluoro-phenyl]-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

HRID 1027433Notes

Reaction equation

HRID 1027433 reaction equation
[ClH:1].C(OC([N:9]1[CH2:36][CH2:35][C:12]2([C:16](=[O:17])[N:15]([C:18]3[CH:23]=[CH:22][C:21]([CH:24]4[CH2:29][CH2:28][CH:27]([N:30]5[CH2:33][CH2:32][CH2:31]5)[CH2:26][CH2:25]4)=[CH:20][C:19]=3[F:34])[CH2:14][CH2:13]2)[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[N:30]1([CH:27]2[CH2:26][CH2:25][CH:24]([C:21]3[CH:22]=[CH:23][C:18]([N:15]4[CH2:14][CH2:13][C:12]5([CH2:35][CH2:36][NH:9][CH2:10][CH2:11]5)[C:16]4=[O:17])=[C:19]([F:34])[CH:20]=3)[CH2:29][CH2:28]2)[CH2:33][CH2:32][CH2:31]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 545918442-[4-(4-Azetidin-1-yl-cyclohexyl)-2-fluoro-phenyl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester

Product 1

HCID 674792242-[4-(4-Azetidin-1-yl-cyclohexyl)-2-fluoro-phenyl]-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared in the same manner as Example 17 by using hydrochloric acid in dioxane to hydrolyze 2-[4-(4-azetidin-1-yl-cyclohexyl)-2-fluoro-phenyl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-466ae1a1e1394e1b83347efc44bcbb35
Source dataset
uspto-grants-2014_05
Patent number
US08735385B2

Reaction notes

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