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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1027434Generated: November 1, 2026

Hydrochloric Acid → 2-[2-Fluoro-4-(4-pyrrolidin-1-yl-cyclohexyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

https://huagongshe.com/reaction/1027434

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant2-[2-Fluoro-4-(4-pyrrolidin-1-yl-cyclohexyl)-phenyl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl esterHCID 54591842—
Solvent1,4-DioxaneHCID 31275—
Product2-[2-Fluoro-4-(4-pyrrolidin-1-yl-cyclohexyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one hydrochlorideHCID 71293859—

Reaction Steps

The title compound was prepared in the same manner as Example 17 by using hydrochloric acid in dioxane to hydrolyze 2-[2-fluoro-4-(4-pyrrolidin-1-yl-cyclohexyl)-phenyl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08735385B2
Source datasetuspto-grants-2014_05
ORD IDord-ddbff0d58ac246a0a033362e174020f0
Source noteuspto-grants-2014_05