Hydrochloric Acid → 2-[2-Fluoro-4-(4-pyrrolidin-1-yl-cyclohexyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

HRID 1027434Notes

Reaction equation

HRID 1027434 reaction equation
[ClH:1].C(OC([N:9]1[CH2:37][CH2:36][C:12]2([C:16](=[O:17])[N:15]([C:18]3[CH:23]=[CH:22][C:21]([CH:24]4[CH2:29][CH2:28][CH:27]([N:30]5[CH2:34][CH2:33][CH2:32][CH2:31]5)[CH2:26][CH2:25]4)=[CH:20][C:19]=3[F:35])[CH2:14][CH2:13]2)[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[F:35][C:19]1[CH:20]=[C:21]([CH:24]2[CH2:29][CH2:28][CH:27]([N:30]3[CH2:34][CH2:33][CH2:32][CH2:31]3)[CH2:26][CH2:25]2)[CH:22]=[CH:23][C:18]=1[N:15]1[CH2:14][CH2:13][C:12]2([CH2:11][CH2:10][NH:9][CH2:37][CH2:36]2)[C:16]1=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 545918422-[2-Fluoro-4-(4-pyrrolidin-1-yl-cyclohexyl)-phenyl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester

Product 1

HCID 712938592-[2-Fluoro-4-(4-pyrrolidin-1-yl-cyclohexyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared in the same manner as Example 17 by using hydrochloric acid in dioxane to hydrolyze 2-[2-fluoro-4-(4-pyrrolidin-1-yl-cyclohexyl)-phenyl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-ddbff0d58ac246a0a033362e174020f0
Source dataset
uspto-grants-2014_05
Patent number
US08735385B2

Reaction notes

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