3,4-Difluorobenzene-1-sulfonyl chloride → 3,4-Difluoro-N-{4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-benzenesulfonamide

HRID 1027439Notes

Reaction equation

HRID 1027439 reaction equation
[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:11][CH2:10][C@H:9]([C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[CH2:8]1.[F:19][C:20]1[CH:21]=[C:22]([S:27](Cl)(=[O:29])=[O:28])[CH:23]=[CH:24][C:25]=1[F:26]>>[F:19][C:20]1[CH:21]=[C:22]([S:27]([NH:18][C:15]2[CH:16]=[CH:17][C:12]([C@H:9]3[CH2:10][CH2:11][CH:7]([N:3]4[CH2:4][CH2:5][CH2:6][C@@H:2]4[CH3:1])[CH2:8]3)=[CH:13][CH:14]=2)(=[O:28])=[O:29])[CH:23]=[CH:24][C:25]=1[F:26]

Participants

3

Reactant 2

HCID 27369133,4-Difluorobenzene-1-sulfonyl chlorideHCID 674791474-[(S)-3-((S)-2-Methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine2×

Product 1

HCID 674794303,4-Difluoro-N-{4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-benzenesulfonamide

Procedure

The title compound was synthesized essentially in the same manner as Example 28 by employing 4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine (Intermediate 14) and 3,4-difluorobenzene sulfonyl chloride.

Sources & evidence

ORD record
ord-0b55fb9f3789401cb485966ea75bbf73
Source dataset
uspto-grants-2014_05
Patent number
US08735385B2

Reaction notes

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